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Three tumors involved the nasal cavity alone, one involved the paranasal sinuses, and two involved both the nasal cavity and paranasal sinuses.
Histologically, the tumors were characterized by a variably cellular proliferation of cytologically bland spindle cells within a collagenous stroma with prominent interspersed branching vessels.
Among these patients, 44 received ICT followed by CCRT, and 44 received CCRT alone with concurrent agents including Cisplatin, Carboplatin, and Cetuximab.
Disease control and survival outcomes were reported after adjusting for age, T stage, N stage, and smoking status. Conclusion: Among patients with p16-positive OPSCC with low-neck and/or N3 lymphadenopathy, ICT followed by CCRT may reduce the risk for distant failure over CCRT alone and lead to improved progression-free survival.
Results: Median follow-up for surviving patients was 47 (range: 13–115) months. Future trials should concentrate on patients at the highest risk of distant metastasis in order to appropriately assess the benefit of ICT.
Patients who received CCRT alone were older than those who received ICT (61 years vs. Solitary fibrous tumors (SFTs) are well recognized in the head and neck region, but rarely arise in the sinonasal tract (SNT).
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EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS).Twelve high-grade EMCAs (12/39, 31%) occurred across all subsets.The median disease-free survival was 80 months (95% confidence interval, 77-84 mo).This tumor shows a remarkable papillary architecture, arising from the surface epithelium and in general showing indolent biologic behavior.
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Stromal invasion developed a large hematoma affecting much of the breast. In general, patient acceptance of the procedure was very high. cells; “dilapidated brick wall” appearance in areas of Pagetoid growth along the wall of the ductule. H&E x 160. d Excised lesion. Moderately pleomorphic, poorly cohesive epithelial.… continue reading »
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