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geographic location, age, gender, ethnicity and body niche.

The nares, throat and perineum are the most prevalent sites for carriage in the general adult population.

Other sites of the skin and the intestine are also frequently colonised.

Thus, a successful establishment is dependent on multiple factors.

Although traditionally considered an extracellular pathogen, there is increasing evidence that staphylococci are able to invade host cells, and that an intracellular lifestyle may facilitate long-term persistence in bone tissue, enabling evasion of antimicrobials and host immune responses.

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